After a transfer to end in 1915, he became an All-America selection and Nebraska went 8-0 on the season. The Cornhuskers had beaten Notre Dame 20-19. Knute Rockne, then a Notre Dame assistant coach, called Chamberlin "the key to Nebraska's victory." For his final college game, November 20, 1915, he moved back to halfback and scored five touchdowns in a 52-7 romp over Iowa.

Guy Chamberlin’s stats and bio went into the College Football Hall of Fame in 1962. After serving in World War I Guy played pro football for eight years. Bears legend, George Halas called him "the greatest two-way end in the history of the game." He was not only a good player but he was a great early coach in the NFL according to the Pro Football Hall of Fame.

In his six coaching seasons, five of which were spent as a player-coach, Chamberlin also won four NFL championships for the Canton Bulldogs in 1922 and 1923, the Cleveland Bulldogs in 1924, and the Frankford Yellow Jackets in 1926. The Pro Football Hall of Fame enshrined Guy Chamberlin in 1965.