Alexander's football legacy extended into the professional ranks. For seven seasons, he played in the nascent National Football League while pursuing his medical career, ultimately specializing in lung diseases and co-founding an early tuberculosis center in New York, earning him the moniker "Doc." He served as a playing coach for the New York Giants in 1926, leading the team to an 8-4-1 record.  

Doc Alexander's accolades include his three All-America honors.

His significant contributions to the sport were formally recognized in 1954 when the National Football Foundation voters inducted him into the College Football Hall of Fame, solidifying his place in gridiron history. His unique ability to excel in the demanding worlds of professional football and medicine underscores a remarkable and enduring legacy.