He had some splash plays almost from the get-go, for as a sophomore at Tech, he intercepted a pass and ran 43 yards against Washington State. As a junior, his stat-line included a 90-yard run from scrimmage against Texas Christian and a 68-yard punt against Southern Methodist. The more he played, the better he got. In his Senior season, Donny was off the charts.

That 1965 season, Anderson ran a kickoff back 100 yards against Oklahoma State, caught ten passes against Arkansas, and scored 17 touchdowns in the season. The Sporting News named him co-winner (with Jim Grabowski of Illinois) of its Player of the Year Award. His 5111 yards on all-purpose running was a Texas Tech record. This includes his career yardage by rushing, receiving, kick returns, and interception returns. The National Football Foundation selected Donny Anderson for entrance into the College Football Hall of Fame in 1989. Donny enjoyed nine seasons at the professional level as a player too. The Pro Football Reference website shares that he spent 6 seasons as a Green Bay Packer winning two Super Bowls and two NFL Championships and three more years as a St Louis Cardinal. During his NFL stint he tallied almost 4700 yards with a 3.9 yards per carry average.