DeLamielleure's football journey began at Michigan State University, where he excelled as a guard and earned All-American honors. His powerful blocking and consistent performance made him a highly sought-after prospect in the 1973 NFL Draft.

The Buffalo Bills selected DeLamielleure in the first round, and he quickly proved his value. He earned All-Rookie honors in his debut season, a testament to his immediate impact. DeLamielleure became a cornerstone of the Bills' offensive line, famously known as the "Electric Company," which powered O.J. Simpson's record-breaking rushing performances. While traditional statistics for offensive linemen are limited, his crucial role as a lead blocker for Simpson's prolific runs speaks volumes about his effectiveness. He was known for his durability and ability to pull and lead blocks, a vital part of the Bills offense.

DeLamielleure's football legacy is deeply intertwined with the Bills' offensive dominance during the 1970s. He was a key component of an offensive line that paved the way for Simpson's historic 2,003-yard rushing season in 1973. His consistent excellence and leadership earned him recognition as one of the premier guards of his era. After his time in Buffalo, he played for the Cleveland Browns, where he continued to play at a high level.

DeLamielleure's accolades include his induction into the Pro Football Hall of Fame in 2003, solidifying his place among the most outstanding offensive linemen. He was selected to eight Pro Bowls and six First-Team All-Pro selections. His All-Rookie selection highlights how quickly he adjusted to the NFL. While precise statistics for offensive linemen of that era are scarce, his consistent presence in the lineup, his role in Simpson's rushing records, and his numerous accolades underscore his significant contributions to the game. His impact on the Bills' offensive success and his consistent excellence throughout his career cement his legacy as a Hall of Fame offensive guard.