Layne's collegiate career was marked by numerous achievements, including All-America honors and the breaking of 11 school records. His success continued into the NFL, where he enjoyed a record-setting career with the Detroit Lions and Pittsburgh Steelers. A highlight of his time with Detroit was his clutch last-second pass that secured the 1953 NFL Championship. Throughout his 15-year NFL career, Layne was recognized for his exceptional play, earning two First-Team All-NFL selections, four Second-Team All-NFL selections, and the 1956 NFL scoring title.

Layne's impact on the game was undeniable. He was inducted into the College Football Hall of Fame in 1968 and the Pro Football Hall of Fame in 1967, solidifying his place among the greatest quarterbacks in NFL history.