After the War, he signed on with the AAFC’s Cleveland Browns and led the League in receiving 3 out of the League's League four years, also setting AAFC records. He was an All-Pro three times, All-NFL twice, and All-AAFC in four seasons. The Pro Football Hall of Fame enshrined Mac Speedie 100 years after his birth in 2020.

More than just statistics, Speedie's story resonates with his resilience and pioneering spirit. He defied expectations, proving that size and past challenges could not hold him back. In a league dominated by hulking running backs and bruising linemen, Speedie carved his niche as a smaller, faster player who excelled with his skill and intelligence.