The Zips football program was established in 1891, making it one of the oldest in college football.
Initially playing as Buchtel College, the team adopted the "Zips" nickname in 1950.
The Zips started in Division 1AA (now FCS) but moved to Division 1A (now FBS) in 1987.

The Zips have participated in various conferences throughout their history, including:
Ohio Athletic Conference (1915-1936, 1946-1965)
Mid-Continent Conference (1978-1979)
Ohio Valley Conference (1980-1987)
Mid-American Conference (MAC) since 1992