Several teams emerged as top contenders throughout the season. The Minnesota Golden Gophers, led by head coach Bernie Bierman, dominated the Big Ten Conference with a perfect 8-0 record. Their powerful play and consistent victories earned them the top spot in the AP Poll. The Golden Gophers were eventually crowned national champions.

Other notable teams included the Duke Blue Devils, who went undefeated in the regular season, and the Notre Dame Fighting Irish, who also had an impressive season.

Key games that highlighted the season included matchups where these dominant teams clashed or faced tough rivals. These contests often determined conference standings and shaped the national rankings.

The season culminated with Minnesota being recognized as the national champion. Their dominant performance throughout the year solidified their place in college football history. The 1941 season is remembered not only for the outstanding play on the field but also for the shadow of war that added a unique dimension to the games.